Heavy Menstrual Bleeding, Improving Knowledge, Improving Lives
Endometrial dysfunction as cause of Heavy Menstrual Bleeding

Endometrial dysfunction


  • Abnormal uterine bleeding caused by a primary disorder of the endometrium. Can be associated with a disruption of mechanisms regulating local endometrial hemostasis with deficiencies in local production of vasoconstrictors and increased local production of substances that promote vasodilation1



  • Abnormal uterine bleeding in a woman with a structurally normal uterus, regular ovulatory cycles and no evidence of coagulopathy or other systemic disease1,2



  • Taking a detailed medical history and excluding other pathologies1,2



  • There are currently no specific therapies to treat endometrial dysfunction2
  • Treatment options may include non-hormonal medications like non-steroidal anti-inflammatories and tranexamic acid and hormonal medications such as oral contraceptives and the levonorgestrel intrauterine system3

Endometrial dysfunction Library

Find more information and download materials on endometrial dysfunction in the teaching and resources library.


  1. Munro MG, et al. Int J Gynaecol Obstet 2011;113:3–13.
  2. Whitaker L & Critchley HO. Best Pract Res Clin Obstet Gynaecol 2016;34:54–65.
  3. Singh S, et al. J Obstet Gynaecol Can 2013;35(5_eSuppl):S1–S28.

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