- Abnormal uterine bleeding caused by a primary disorder of the endometrium. Can be associated with a disruption of mechanisms regulating local endometrial hemostasis with deficiencies in local production of vasoconstrictors and increased local production of substances that promote vasodilation1
- Abnormal uterine bleeding in a woman with a structurally normal uterus, regular ovulatory cycles and no evidence of coagulopathy or other systemic disease1,2
- Taking a detailed medical history and excluding other pathologies1,2
- There are currently no specific therapies to treat endometrial dysfunction2
- Treatment options may include non-hormonal medications like non-steroidal anti-inflammatories and tranexamic acid and hormonal medications such as oral contraceptives and the levonorgestrel intrauterine system3
- Munro MG, et al. Int J Gynaecol Obstet 2011;113:3–13.
- Whitaker L & Critchley HO. Best Pract Res Clin Obstet Gynaecol 2016;34:54–65.
- Singh S, et al. J Obstet Gynaecol Can 2013;35(5_eSuppl):S1–S28.